Saturday, November 18, 2017

How Do We Solve the Problems We Create?

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If you read many self-help books, or listen to any motivational speakers or even if you just read the occasional inspiration quote that get posted by that one friend on facebook (you know the one I’m talking about.) You start to realize that certain stories or analogies get used over and over again. One of the analogies I’ve encountered on several different occasions concerns the problems that arise when you help a chick to hatch. Here’s an example of what I mean from the blog of a licensed clinical social worker:


Some new hatchers assist emerging chicks too soon and/or too thoroughly. Anxiety at this stage is high, especially for first-timers.  They misinterpret the needs of the chick and prematurely intervene, sometimes with dire consequences.  Some of these dire consequences are due directly to the well-intentioned intervention (ex: hemorrhaging due to torn membranes) and some are due to the consequences of the well-intentioned intervention (ex: the chick’s circulation wasn’t allowed to pump hard enough to allow them to warm themselves up once hatched).  The bottom line is, chicks actually need to peck their own way out of their own shell.  Without the strengths developed within their struggle, they are left vulnerable to their environment.


This is true for people too.  Our life experiences (including how we respond to them) are our shells, and figuring out how to navigate them effectively prepares us to effectively navigate our world.


Perhaps you’ve encountered this analogy or maybe you haven’t, but either way, this post is going to be about the necessity of struggle, which is the kind of thing that calls for an analogy, or an inspirational story. But as usual rather than just starting with story, I have to explain the whole thing and make it complicated. In fact, as a further complication, now that I’m re-telling it, and in the process, lending the enormous credibility of my blog to the whole thing, I feel compelled to see if there’s any truth to it.


A quick search seems to indicate that it is one of those things that’s mostly true, though as with so many things there are caveats. Yes, the general recommendation is that you shouldn’t help the chick hatch. That said, it’s not an automatic death sentence for the chick if you do. It does appear that more often than not if you help it hatch it will probably later die, but that may be less about the struggle giving the chicken the necessary tools to live and more the fact that if a chick is too weak to break out of its shell that it’s probably too weak to survive period. So perhaps this isn’t the best analogy, but I’m too lazy to find another one, also if you don’t think a certain amount of  struggle is necessary then I’m honestly not sure what you’re doing here in the first place.


However, in the interests of being thorough I suppose I could spend a small amount of time trying convince those on the fence that struggle is, in fact necessary. Though I would think the chick and the shell thing would be all the proof anyone would need, particularly given how directly and unequivocally I presented it. But I suppose it’s possible it didn’t convince you.


In that case, to understand struggle, let’s start at the highest level, you’re either religious, or you’re not. If you are religious, than struggle is built in to basically all religions both doctrinally and observationally. On the other hand, if you’re not religious than natural selection is all about the struggle for survival. Outside of that, I suppose there’s a third option, where you believe in some sort doctrine-free spiritualism which doesn’t include any struggle at all, something along the lines of The Secret, but if that’s the case then let me say, and let there be no mistake about whether I’m serious, because I am, you’re an idiot. And you should go away. Meaning you’re either an idiot (and we can ignore that category because I just told them to leave.) Or you believe struggle is part of existence.


But wait, you may be saying. You claimed that struggle is necessary. Going from being part of life to being necessary is still a big leap, one which you haven’t made. Very well, for the religious, one has to assume that struggle is necessary on some level or it wouldn’t exist. For the non-religious, non-idiots, it’s a little more complicated, and in fact it is in this area where I’ll be spending most of my time.


From here on out I’m going to assume that we all agree that struggle is part of existence (the idiots having been banished) and that all that’s left is determining whether it’s actually necessary. On this point there are two ways of thinking:


Camp One: These are the people who believe that struggle is so deeply intertwined with how things work from an evolutionary standpoint, that it would be impossible to eradicate it entirely without consequences that are worse than the initial suffering. Such consequences might include, but are certainly not limited to, bodily atrophy, diseases, autoimmune disorders, apathy, depression, lack of offspring etc.


Camp Two: These are people who believe the opposite, that technology will eventually enable us to eliminate struggling (and presumably also pain and suffering and malaria and auto-play videos on websites.) They will admit that perhaps struggle is necessary now, a la the chick and the egg, or needing to exercise to stay healthy, but that it’s on it’s way out. Yes, we once lived in a world where struggle was necessary to toughen us up, develop immunities, exercise willpower, and so forth, but that all of the things which were once “powered” by struggle will eventually be powered some other way, or be done away with entirely.


I think both groups would agree that it’s worthwhile and benevolent to remove unnecessary or counterproductive struggle, and by extension unnecessary pain and suffering. The questions which divides to two are how cautious do we need to be before we declare that something is unnecessary or counterproductive and is there some line, past which, we should not proceed?


At this point you would almost certainly like an example. And one of the best known involves the recent increase in the occurrence of allergies. There are several theories for why this is happening, but almost all of them revolve around allergies being a by product of some overzealous attempts to eliminate a form of natural struggle.


The best known of these theories is the hygiene hypothesis. The idea here being that in the “olden days” children were exposed to enough pathogens, parasites and microorganisms that their immune system had plenty of things to keep it occupied, but that now we live in an environment which is so sterile that the immune system, lacking actual pathogens, decides to overreact to things like peanuts. As I said this is just one theory, but all of the alternative theories also involve the absence of some factor which humanity previously considered a struggle. Also it is interesting, speaking of peanuts, that the NIH recently reversed their recommendation from avoiding peanuts until children were at least three, to recommending that you give peanuts to kids as soon as they're ready for solid food (approximately four months old.) Which obviously follows from this model.


As I said I’m not claiming that we know with absolute certainty that allergies are increasing because we’ve eliminated some necessary struggles. Though I will say that if that is the case, Most affected people, particularly those with the severest allergies, would trade those allergies in a heartbeat for growing up in a slightly less hygienic environment. Which I suppose makes this a point in the group one column. This is something where eliminating the struggle was not worth the tradeoff.


If this trend was limited to allergies, then I wouldn’t be writing about it, but we’re also seeing dramatic increases in the diagnosis rate of autism. And while part of this is certainly due to it being diagnosed more, almost no one thinks that this explains 100% of the increase. On top of allergies and autism, if you were following the news over the summer you may have seen a story about sperm counts halving in the last 40 years. This one is less well understood than the allergy problem, but it almost certainly represents something we’re doing to make life easier, which has the unforeseen side effect of reducing sperm counts, and by extension fertility.


These first three examples may all be genetic issues, but there are also cultural issues with modernity. For example the number of suicides and attempted suicides has skyrocketed in recent years, particularly among young people, whom you would expect to be the most impacted by recent cultural changes. Obviously there are lots of people who feel the increase comes because teens are struggling too much, but any sober assessment of historical conditions would have to conclude that this is almost certainly ridiculous. On the contrary, as I have said previously, if you remove struggle from a children’s life then you also remove the reasons why they might be unhappy. And, if after all these things are removed, they are still unhappy, the logical conclusion, since it’s nothing external, is that it has to be internal, and from that conclusion suicide can unfortunately often follow.


You may disagree with this theory, and may be it is only a temporary blip, unrelated to any of our misguided attempts to make life easier for kids, not evidence of a long term trend, but how sure are you of this, and are you willing to bet the lives of thousands of young people on whether or not you’re right?


On this last point you may be noticing some similarities to a previous post I did about the book Tribe, by Sebastian Junger. As you may or may not remember, stressful situations improved mental health. And as wars become less stressful mental health appears to be getting worse. If you don’t remember that post, this paragraph from Tribe is worth repeating:


This is not a new phenomenon: decade after decade and war after war, American combat deaths have generally dropped while disability claims have risen. Most disability claims are for medical issues and should decline with casualty rates and combat intensity, but they don’t. They are in an almost inverse relationship with one another. Soldiers in Vietnam suffered one-quarter the mortality rate of troops in World War II, for example, but filed for both physical and psychological disability compensation at a rate that was 50 percent higher… Today’s vets claim three times the number of disabilities that Vietnam vets did, despite...a casualty rate that, thank God is roughly one-third what it was in Vietnam.


As I pointed out back then, if you parse this out, Vietnam vets had a disability per casualty rate that was six times higher than World War II vets and current vets have a disability per casualty rate 54 times as high as the World War II vets. All of this is to say that there is significant evidence that making things easier (less of a struggle) doesn’t make things better.


For the most extreme view on this problem let’s turn to a response to 2016 EDGE Question of the Year, What do you consider the most interesting recent [scientific] news? What makes it important? This particular response, by John Tooby, was titled: The Race Between Genetic Meltdown and Germline Engineering. And the gist of the article is that previous to that advent of modern medicine most people died, and this was especially true of individuals with harmful genetic mutations. This is no longer the case, and thus humanity is accumulating an “unsustainable increase in genetic diseases”.


The article makes several fascinating points:


  • On the necessity of a certain number of people to die before reproducing:


For a balance to exist between mutation and selection, a critical number of offspring must die before reproduction—die because they carry an excess load of mutations.


  • On how fast this problem can escalate


Various naturalistic experiments suggest this meltdown can proceed rapidly. (Salmon raised in captivity for only a few generations were strongly outcompeted by wild salmon subject to selection.)


  • He even goes on to say that this may be the explanation of the worldwide decline in birthrates among developed nations


If humans are equipped with physiological assessment systems to detect when they are in good enough condition to conceive and raise a child, and if each successive generation bears a greater number of micro-impairments that aggregate into, say, stressed exhaustion, then the paradoxical outcome of improving public health for several generations would be ever lower birth rates. One or two children are far too few to shed incoming mutations.


This strikes me as one of those obviously true things that no one wants to think about. But it also dovetails in very well with the theme of the post, and brings up an issue central to the claims of the second group, those who believe all struggle and suffering can be eliminated through technology. In this case we know exactly how to fix the problem, it’s even in the title. We just have to master germline, or more broadly, genetic engineering. Furthermore this isn't some hypothetical technology with no real world examples. The CRISPR revolution promises that this is something we could do very soon (if not already). The chief difficulty at this point is not in editing the genes, but in knowing what genes to edit. And I don’t want to minimize the difficulties involved in that effort, but there’s definitely nothing about the idea which seems impossible. Nearly all experts would say it’s not a matter of if, but when.


As a matter of fact mastering genetic and germline engineering would probably help with all of the examples we’ve looked at. Despite what people want to claim there’s a genetic component to nearly everything, certainly with autism, but probably also with allergies and low sperm counts and even suicide risk. In theory anything that can be treated with a pill could be treated with genetic engineering and this treatment would probably involve fewer long term side effects. At least health-wise…


So there you have it, the second group is correct, all we have to do is improve CRISPR to the point where we can genetically modify humans, do some experiments to figure out which genes do what, and the negative mutation load, and the low sperm count and the allergies and the autism, and possibly even the elevated suicide will all go away. Struggle was necessary to healthy development, but once we master the genome it won’t be, at least not for anything that can be fixed with genetics. In other words as Tooby’s title declares, we’re in a race between genetic meltdown and germline engineering. Obviously we have to win that race, but as long as we do that, everything will be fine right?


Are you sure about that? From where I sit, if we develop genetic and germline engineering of the kind Tooby is talking about, that’s not the end of our problems, it may be the end of certain specific problems, but it’s the beginning of a whole new set of problems. (Perhaps you’ve seen the movie Gattaca?)


I know that the current laws on genetic engineering are still embryonic (get it? embryonic?) But it is nevertheless true that most people already recoil at the thought of designer babies, or really anything involving modifying genes much beyond doing it as a means of curing disease. Up until this point I’ve used genetic and germline engineering somewhat interchangeably, but they are different. Germline engineering is the process of making modifications which are heritable. If you use it to make someone exceptionally strong, their children would have a greater chance of being exceptional strong as well. This is why Tooby specifically talks about a race between germline engineering and genetic meltdown, because whatever fixes you made would have to transfer for it to be of any use. One of the reasons this differentiation is important is that the US has mostly banned germline engineering, beyond this you can find countless articles debating whether it’s ethical or not.


If, despite the ban, and the ethical questions and people’s distaste at the idea of designer babies, if Tooby is to be believed, we really don’t have any choice in the matter, which means, along with solving the genetic meltdown problem we buy ourselves a whole host of new problems. Including:


Greater divisions between rich and poor: This problem is bad enough already, but toss in the ability for the rich to increase their child’s IQ and health and suddenly you’ve got gaps which no amount of affirmative action, or protests are going to fix.  Also there’s a non-trivial chance that this ends up being a positive feedback loop. With the new smarter richer groups discovering additional positive mutations to add to the mutations they already have at a faster and faster rate.


Racial problems: This is similar to above but probably even more radioactive. Radioactive enough that I don’t even want to speculate. (I’ll give you one hint: transracial.) But I’m sure you can imagine several potential scenarios where this technology makes everything a whole lot worse.


Bioweapons: If you can develop positive mutations then you can develop negative mutations, and while the delivery for those would still need to be accomplished, none of the technology makes this problem harder and it may make it a lot easier. Which takes us to our next point.


Limited Genetic Diversity: Once people start making modifications they will coalesce around certain mutations, leading to a great number of people whose genetic diversity is significantly less than the “default”. Also as we know there are some “bad” mutations which have good side effects (the classic example being sickle cell anemia.) If a disease mutated to affect one, it would be equally effective against all of them. And following from the last point that disease wouldn’t have to be natural.


Different “breeds”: At some point when this has gone on long enough (and really not even all that long) it’s not inconceivable that you could have various breeds of humans, as different from one another as great danes are from toy poodles. How the world deals with something like this is well beyond my ability to predict, but I can’t imagine that it makes things better.


The good news for Tooby, but the bad news for anyone worried about any of the above is that CRISPR is not the Manhattan Project. It doesn’t take billions of dollars and millions of man hours, it’s something you can do from home. Now germline engineering is more difficult, but not that much more so. Certainly it’s not the kind of thing the US could keep any other country from doing if they wanted to.


All of this has taken us pretty far from the topic of whether struggle is necessary, and our two groups. But if nothing else you can begin to see the complexities involved in group two’s assertion that we can eventually solve everything through technology. Yes you can help a chick hatch, but most of the time it will die. Yes, you can make war safer and less connected to the rest of life, but PTSD will go way up. Yes modern medicine can keep people alive who otherwise would have died, but their negative mutations end up in the gene pool. Yes we can solve that with Germline engineering, but that creates a whole new set of problems. Yes we can make life materially better for everyone by using fossil fuels but the resultant CO2 causes global warming.


This is a complicated subject and I am not urging a retreat to some kind of prelapsarian past. But I think we should question the idea that any struggle is bad, that technology and progress has all the answers, and that we can solve all the problems we create.





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2 comments:

  1. Hmmm, I suspect this might tie into the whole Drake Equation / Alien Life Paradox. Assuming we need a large population to populate a planet in another star system (let's say 5,000 individuals) and a large startup 'biome' of diverse bacteria, viruses, fungi etc.. Assume also we are limited to light speed physics and 'normal physics' which says it's pretty much impossible to gather enough energy to get anything larger than a few atoms up to near light speed, we are left with the conclusion to go from one star to another would require hundreds to thousands of years and a very large colonizing group.

    Given this how do you deal with genetic diversity given that you'll need, say, 100 generations in a contained convoy making its way to a new star and planet and then what would probably be a very high level of fitness in the new environment. CRISPR is pretty good at slicing and dicing known genes but this seems to require phenotype editing. A phenotype is an expression of a gene. Knowing which genes give a bird its wings is one thing, for example, but it's quite another thing to design a winged human from scratch in one shot.

    It seems at a min. interstellar colonization would require the ability to manage genetics on the fly to keep the necessary diversity and 'robustness' to adversity needed for the new planet. I'm not sure this problem can be resolved with a tech fix.

    In economics there's the famous 'socialist calculation problem'. Basically a central planner cannot have access to all the information and time needed to calculate the optimal allocation of production over the entire economy compared to decentralized planners. This is more of an NP type problem, better computers and more data collection doesn't solve it. Genetics and evolution also seems to follow a market process so this seems like it would likely be a huge hurdle for interstellar migration.

    A high hurdle doesn't mean it's impossible but it does increase the odds that fewer intelligent civilizations can leap it or would want to make the effort to leap it.

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    1. I'm glad that someone else sees how Fermi Paradox eventually ties into so many of the issues modernity has created. And you bring up an interesting point. As I have previously mentioned in conversations like this I have seen estimates as low as 80, but what if those 80 people are modern people deep into genetic meltdown. I'm still not sure that that takes 80 to 5000 (though 80 is probably too optimistic regardless) but it does make all sorts of things more difficult, like Elon Musk's Mars plan.

      As you point out, it's hard to say how much of a difference genetic engineering could make to this problem. Particularly when you toss in the radiation any interstellar voyage entails. And the challenges of trying to live somewhere vastly different than earth.

      But, indeed as you say, on top of everything else this does appear to be another explanation for Fermi's paradox.

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